Side - Effects

1. Pain – The patient usually experiences only mild pain after treatment of cutaneous metastases. However, there can be severe pain for 1-2 weeks from treatment of tumors in the oral cavity.

2. Muscle contraction – Muscle contraction with SENNEX®  ElectroChemoTherapy (ECT) is usually not painful. But the patient should be informed before treatment under local anesthesia.

3. Necrosis – Necrosis is uncommon in ECT treatment of small tumors. It is more common in tumors exceeding 3 centimeters.

4. Hyper-pigmentation – Skin hyper-pigmentation is unusual, but may occur if Bleomycin is used.

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Treatment localizations with increased risk of serious complications
  • When tumors in the vicinity of the common/internal carotid artery are treated, there is an increased risk of ischemic stroke. Ultrasound is usually helpful.
  • When tumors in the oral cavity or in the base of the tongue are treated, there is an increased risk of swelling that may compromise the airway. Delayed extubation or a tracheostomy is recommended in these cases. 
Exclusion from treatment
  • Pregnancy.
  • Allergy to the chemotherapeutic drug.
  • The presence of a pacemaker that cannot be turned off during the treatment.
  • Tumors with periosteal and/or bone invasion.
Contraindications
  • If the patient has previously received 400.000 IU of Bleomycin, only Cisplatin can be used. The Lifetime dose of Bleomycin is 400.000 IU. This dose cannot be exceeded.
  • If the patient has pulmonary fibrosis, intravenous Bleomycin should not be used.
  • If serum creatinine > 150 micromol/l, Bleomycin should not be used.